Let’s start with the PDRN of it all. Short for polydeoxyribonucleotide, PDRN is a skincare ingredient derived from ultra-purified salmon DNA fragments. It first gained traction in Korean dermatology clinics via injectable treatments like Rejuran, where it’s prized for its ability to support cellular repair, reduce inflammation, and encourage overall skin regeneration. In topical formulas, proponents say it can help hydrate, strengthen, and rebalance the skin barrier—so its expansion into categories beyond skincare, like haircare, feels like a natural next step. Several Medicube bestsellers already feature the ingredient: The brand’s PDRN Pink Collagen range includes everything from toner pads to overnight masks to serums. (Our beauty director raved about the PDRN Pink Collagen Gel Masks in particular for achieving a juicy, “glass skin” effect.) I’ve used various PDRN skincare throughout the last year, and in my experience, the ingredient is a gamechanger for barrier repair. That said, a quick fix it’s not: You might not notice a huge difference at first, but over time, your skin will look and feel overall calmer and healthier—at least that’s been my experience thus far. I was hoping Medicube’s PDRN shampoo would have a similar effect on my scalp, which often gets dry and itchy.
