Nasdaq, S&P 500 Open Higher to Start Week; Novo Nordisk Plummets After Ozempic Alzheimer’s Miss

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Happy Monday. This is TheStreet’s Stock Market Today for Nov. 24, 2025. You can follow the latest updates on the market here in our daily live blog.

The U.S. markets are now open. The Nasdaq (+1.33%) is starting the week on strong footing, trailed by the S&P 500 (+0.75%). Meanwhile, the Russell 2000 (+0.35%) and Dow (+0.25%) are also up, albeit, bested by some margin.

Updates will be added here shortly.

Weight loss pills have been floated as a possible treatment for everything. However, Alzheimer’s is apparently not one of those diseases easily treated by the burgeoning GLP-1 class of drugs.

Novo Nordisk (-10.4%) is plummeting this morning, dragging down shares of Eli Lilly (-1%) after its weight loss pill Ozempic did not “demonstrate a statistically significant reduction in Alzheimer’s disease progression” in a phase 3 study.

Novo’s Executive VP of Research and Development says that they pursued the study based on “significant unmet need in Alzheimer’s as well as a number of indicative data points,” but the study was largely seen as a long-shot. There are likely other indications where the blockbuster drug could be trialed to greater effect, much like the companies did with weight loss.

Aside from the GLP-1 names, here are the movers for today, per MarketWatch:

Inspire Medical Systems (+18.5%) is jumping after an upgrade from Stifel, which bumped the company’s share target to $110 amid higher reimbursements. It’s joined by Ingredion (+9.8%), which has faced negative news in recent weeks but announced a deal to exit its stake in a joint venture with partner Amyris. Finally, Centene (+8.3%) is jumping amid new analyst upgrades and hopes of a new Republican health care plan which will extend Obamacare subsidies for at least two years.

On the other end of the market, Novocure (-7.3%) appears to be falling, joined by New York Times Co (-5.5%), Paycom (-4.8%), and Popular Inc (-3.88%).

Good morning. After a rough week for U.S. equities — which saw the Nasdaq decline 2.2% despite a surprising rally to end the week — the market is ticking higher this morning. Futures are pointing to a healthy open for the major indexes, which are up between 0.17% and 0.68%.

Despite the recent jitters in markets, banks are putting out their guesswork for where things could be in a year’s time — and they’re still feeling bullish, apparently. Here’s just a cropping of the strangeness we’re hearing:

• Deutsche Bank sets 2026 year-end S&P 500 target at 8,000

• Morgan Stanley raises 12-month target for S&P 500 to 7,800

• JPMorgan analysts forecast Brent Crude “may” decline into the $30s in 2027

Remember for a moment that the S&P 500 closed Friday at 6,602.99 and Brent continuous contract is sitting at 62.09 this morning. These are some fascinating predictions, even if you can sort of directionally see where they’re coming from.

That said, let’s take a look at what’s going on today:

Monday is generally a slow day for earnings, especially when you’re closer to the end of the season than the start. Here’s what to expect, mostly after the market closes:

This morning, the Dallas Fed Manufacturing Index will be out at 11:30 a.m., our only serious report for the day. In its last showing, it registered a -5. It’ll precede an exceptionally busy Tuesday, which will see a deluge of establishment data released.

This story was originally reported by TheStreet on Nov 24, 2025, where it first appeared in the Latest Business & Market News section. Add TheStreet as a Preferred Source by clicking here.