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Home Financial Markets

This Will Be Wall Street’s Next Trillion-Dollar Stock

November 16, 2025
in Financial Markets
0
This Will Be Wall Street's Next Trillion-Dollar Stock


  • After a rapid rise, Eli Lilly needs only an 11% gain to hit $1 trillion in market value.

  • Revenue is expected to rise 26% next year, helped by its weight-loss products.

  • If Eli Lilly hits current projections, a $1 trillion valuation for the stock is assured.

  • 10 stocks we like better than Eli Lilly ›

The $1 trillion club in the stock market is exclusive. Only 10 companies currently make the cut on U.S. exchanges, with members making up some of the best-known companies in the world, including Nvidia, Apple, and Microsoft.

Getting to the $1 trillion mark in market capitalization takes a lot of hard work and good fortune. The next company that I see hitting that barrier is closing in rapidly — and I think it will join the trillion-dollar club within the next year.

Eli Lilly (NYSE: LLY) is one of the world’s best-known pharmaceutical companies, most popular in recent years due to its work in diabetes and weight loss treatments.

It is the maker of Mounjaro, which is the brand name of tirzepatide, as a treatment for type 2 diabetes; it also sells a version of tirzepatide under the name Zepbound for weight management. Both have massive growth windows — in the third quarter Mounjaro sales increased $3.4 billion from a year ago to $6.5 billion, and Zepound sales increased $2.3 billion to $3.58 billion.

Make no mistake: Anti-obesity drugs are a huge opportunity for Eli Lilly. Federal government statistics estimate that 43.1% of the U.S. adult population is obese. Grand View Research estimates that the global anti-obesity drug market was $6.6 billion in 2023 and will reach $77.24 billion by 2030, for a compound annual growth rate of 31.66%.

Image source: Getty Images.

Eli Lilly has other drivers as well, such as Jaypirca, which is a treatment for leukemia and small lymphocytic lymphoma that generated $143 million in third-quarter revenue as total prescriptions rose 61% from a year ago. Ebglyss, which treats eczema, saw third-quarter sales of $127 million and prescriptions were up 41% from the second quarter. Sales of the cancer drug Verzenio accounted for $1.4 billion in sales, up 7% from a year ago.

But Zepound and Mounjaro have the biggest impact, accounting for $10.1 billion of the company’s $17.6 billion in revenue for the third quarter. That helped Lilly see overall revenue jump 54% from a year ago, and earnings per share increase from $1.07 to $6.21.

Eli Lilly is well on its way to the trillion-dollar club. The stock price is up 30% so far this year; with a total capitalization of $899 billion now, Lilly only needs another 11% gain to hit the $1 trillion mark.

The company brought in $59.42 billion in revenue in the last 12 months and is projected to record a whopping $75.3 billion in revenue next year — a 26% increase. Currently, Eli Lilly has a forward price-to-sales ratio of 14.1. Assuming it hits that $75.3 billion revenue mark and with a P/S ratio of 14.1, the market cap would come in at $1.06 trillion at the end of 2026.

That’s not out-of-the-box thinking at all. In fact, I think it’s inevitable.

Eli Lilly is going to continue to grow its market share in diabetes and weight loss drugs. It’s building out its capacity, spending billions to build drug manufacturing sites in Virginia and Texas, and expanding a facility in Puerto Rico. It’s also investing in artificial intelligence by announcing a partnership with Nvidia to promote and accelerate new drug discoveries.

And it has a deep pipeline of potential drugs and therapies, including medications to treat ulcerative colitis, Alzheimer’s Disease, cancer, skin conditions, and diabetes. Those investments will be great for Eli Lilly’s long-term prospects, providing investors with an opportunity to invest in a company with both consistent profits and hypergrowth possibilities.

However, in the short term, Lilly’s unique position in weight loss medications and diabetes gives it serious momentum — and its march to a $1 trillion valuation seems all but assured.

Before you buy stock in Eli Lilly, consider this:

The Motley Fool Stock Advisor analyst team just identified what they believe are the 10 best stocks for investors to buy now… and Eli Lilly wasn’t one of them. The 10 stocks that made the cut could produce monster returns in the coming years.

Consider when Netflix made this list on December 17, 2004… if you invested $1,000 at the time of our recommendation, you’d have $599,784!* Or when Nvidia made this list on April 15, 2005… if you invested $1,000 at the time of our recommendation, you’d have $1,165,716!*

Now, it’s worth noting Stock Advisor’s total average return is 1,035% — a market-crushing outperformance compared to 191% for the S&P 500. Don’t miss the latest top 10 list, available with Stock Advisor, and join an investing community built by individual investors for individual investors.

See the 10 stocks »

*Stock Advisor returns as of November 10, 2025

Patrick Sanders has positions in Nvidia. The Motley Fool has positions in and recommends Apple, Microsoft, and Nvidia. The Motley Fool recommends the following options: long January 2026 $395 calls on Microsoft and short January 2026 $405 calls on Microsoft. The Motley Fool has a disclosure policy.

Prediction: This Will Be Wall Street’s Next Trillion-Dollar Stock was originally published by The Motley Fool

Editorial Team

Editorial Team

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